Sennoside B

Modify Date: 2024-01-01 19:02:52

Sennoside B Structure
Sennoside B structure
Common Name Sennoside B
CAS Number 128-57-4 Molecular Weight 862.739
Density 1.7±0.1 g/cm3 Boiling Point 1144.8±65.0 °C at 760 mmHg
Molecular Formula C42H38O20 Melting Point N/A
MSDS Chinese USA Flash Point 348.6±27.8 °C

 Use of Sennoside B


Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2].

 Names

Name sennoside B
Synonym More Synonyms

 Sennoside B Biological Activity

Description Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2].
Related Catalog
References

[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422.

[2]. Chen YC, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 1144.8±65.0 °C at 760 mmHg
Molecular Formula C42H38O20
Molecular Weight 862.739
Flash Point 348.6±27.8 °C
Exact Mass 862.195618
PSA 347.96000
LogP 1.88
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.763

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R22
Safety Phrases 22-45
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  0

DownStream  2

 Articles25

More Articles
The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.

Biol. Pharm. Bull. 35(12) , 2204-8, (2012)

Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinant...

The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.

Biol. Pharm. Bull. 34(9) , 1438-42, (2011)

Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influe...

Effects of optimized-SopungSunkiwon on memory impairment and enhancement.

Neurosci. Lett. 491(2) , 93-8, (2011)

Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investiga...

 Synonyms

SennosideB
[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-
Sennoside B
EINECS 204-895-0
MFCD00151528
(9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
(9R,9'S)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
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