BRD-7389

Modify Date: 2023-01-15 19:11:50

BRD-7389 Structure
BRD-7389 structure
Common Name BRD-7389
CAS Number 376382-11-5 Molecular Weight 366.41200
Density N/A Boiling Point N/A
Molecular Formula C24H18N2O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of BRD-7389


BRD7389 is a specific RSK family kinase inhibitor with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells[1].

 Names

Name bas 05532738
Synonym More Synonyms

 BRD-7389 Biological Activity

Description BRD7389 is a specific RSK family kinase inhibitor with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells[1].
Related Catalog
Target

RSK1:1.5 μM (IC50)

RSK2:2.4 μM (IC50)

RSK3:1.2 μM (IC50)

CDK5/p35:6.5 μM (IC50)

DRAK1:2.8 μM (IC50)

FLT3:3.5 μM (IC50)

PIM1:3.7 μM (IC50)

PKG1α:6.5 μM (IC50)

SGK:13.8 μM (IC50)

In Vitro BRD7389 (0.425-6.8 μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85 μM[1]. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[1]. BRD7389 also increases β-cell-specific gene expression in primary human islet cells[1]. BRD7389 (1 μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation[2]. RT-PCR[1] Cell Line: Mouse α-cell line Concentration: 0.425, 0.85, 1.7, 3.4, 6.8 μM Incubation Time: 3 days and 5 days Result: Up-regulated expression of Pdx1. Cell Proliferation Assay[2] Cell Line: SNU-407 colon cancer cell Concentration: 1 μM Incubation Time: Added 30 min prior to Carbachol treatment (48 h) Result: Almost completely blocked Carbachol (1 mM)-stimulated cell proliferation.
References

[1]. Fomina-Yadlin D, et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104.

[2]. Park YS, et al. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012 Nov;370(1-2):191-8.

 Chemical & Physical Properties

Molecular Formula C24H18N2O2
Molecular Weight 366.41200
Exact Mass 366.13700
PSA 62.22000
LogP 4.87940

 Safety Information

Hazard Statements H413
RIDADR NONH for all modes of transport

 Synonyms

hms1493i11
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: BRD 7389
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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