BRD-6929
Modify Date: 2024-01-16 01:52:39
BRD-6929 structure
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Common Name | BRD-6929 | ||
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| CAS Number | 849234-64-6 | Molecular Weight | 351.42200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H17N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD-6929BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3]. |
| Name | Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl] |
|---|---|
| Synonym | More Synonyms |
| Description | BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3]. |
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| Related Catalog | |
| Target |
HDAC1:1 nM (IC50) HDAC2:8 nM (IC50) HIV |
| References |
[1]. Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147 |
| Molecular Formula | C19H17N3O2S |
|---|---|
| Molecular Weight | 351.42200 |
| Exact Mass | 351.10400 |
| PSA | 112.46000 |
| LogP | 4.93520 |
| 4-(acetylamino)-n-[2-amino-5-(2-thienyl)phenyl]-benzamide |