BRD-6929

Modify Date: 2024-01-16 01:52:39

BRD-6929 structure	Common Name	BRD-6929
	CAS Number	849234-64-6	Molecular Weight	351.42200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₇N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BRD-6929

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].

Name	Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]
Synonym	More Synonyms

Description	BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:1 nM (IC50) HDAC2:8 nM (IC50) HIV
References	[1]. Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147 [2]. Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323. [3]. Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273.

Molecular Formula	C₁₉H₁₇N₃O₂S
Molecular Weight	351.42200
Exact Mass	351.10400
PSA	112.46000
LogP	4.93520

4-(acetylamino)-n-[2-amino-5-(2-thienyl)phenyl]-benzamide

DC Chemicals Limited
China
Product Name: Merck60
Price: $Inquiry/25mg $458.0/5mg $758.0/10mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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