NiclosaMide-13C6 hydrate (see Data Sheet)

Modify Date: 2024-01-13 14:34:24

NiclosaMide-13C6 hydrate (see Data Sheet) structure	Common Name	NiclosaMide-13C6 hydrate (see Data Sheet)
	CAS Number	1325808-64-7	Molecular Weight	333.076
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₇₁₃C₆H₈Cl₂N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NiclosaMide-13C6 hydrate (see Data Sheet)

Niclosamide-13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

Name	5-Chloro-N-[2-chloro-4-nitro(13C6)phenyl]-2-hydroxybenzamide
Synonym	More Synonyms

Description	Niclosamide-13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> JAK/STAT Signaling >> STAT
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Ren, X., et al., Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Medicinal Chemistry Letters, 2010. 1(9): p. 454-459. [3]. Wu CJ, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6. [4]. Chen, M., et al., The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry, 2009. 48(43): p. 10267-74. [5]. Jin, Y., et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res, 2010. 70(6): p. 2516-27.

Density	1.6±0.1 g/cm3
Molecular Formula	C₇₁₃C₆H₈Cl₂N₂O₄
Molecular Weight	333.076
Exact Mass	332.006256
Index of Refraction	1.709

Hazard Codes	Xi
Risk Phrases	38-41
Safety Phrases	26-39

5-Chloro-N-[2-chloro-4-nitro(13C6)phenyl]-2-hydroxybenzamide

Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl-1,2,3,4,5,6-13C6)-2-hydroxy-

NiclosaMide-13C6 hydrate (see Data Sheet)

Use of NiclosaMide-13C6 hydrate (see Data Sheet)

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms