coenzyme B12

Modify Date: 2024-01-02 17:03:18

coenzyme B12 Structure
coenzyme B12 structure
 Common Name coenzyme B12
CAS Number 13870-90-1 Molecular Weight 1579.582
Density N/A Boiling Point N/A
Molecular Formula C72H99CoN18O17P Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of coenzyme B12


Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase[1]

 Names

Name cobamamide
Synonym More Synonyms

 coenzyme B12 Biological Activity

Description Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase[1]
Related Catalog
In Vitro Adenosylcobalamin serves as the cofactor for a group of enzymes that catalyze unusual rearrangement or elimination reactions[1].
References

[1]. Kumudha A, et al. Characterization of vitamin B12 in Dunaliella salina. J Food Sci Technol. 2016 Jan;53(1):888-94.

[2]. Marsh EN, et al. Adenosylcobalamin enzymes: Theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64.

 Chemical & Physical Properties

Molecular Formula C72H99CoN18O17P
Molecular Weight 1579.582
Exact Mass 1578.658325
PSA 583.18000
LogP 6.19200
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GG3800000
CHEMICAL NAME :
Cobinamide, O-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
CAS REGISTRY NUMBER :
13870-90-1
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C72-H100-Co-N18-O17-P
MOLECULAR WEIGHT :
1579.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GG3800000
HS Code 2936260000

 Customs

HS Code 2936260000

 Articles47

More Articles
Thermophilic Coenzyme B12-Dependent Acyl Coenzyme A (CoA) Mutase from Kyrpidia tusciae DSM 2912 Preferentially Catalyzes Isomerization of (R)-3-Hydroxybutyryl-CoA and 2-Hydroxyisobutyryl-CoA.

Appl. Environ. Microbiol. 81 , 4564-72, (2015)

The recent discovery of a coenzyme B12-dependent acyl-coenzyme A (acyl-CoA) mutase isomerizing 3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in the mesophilic bacterium Aquincola tertiaricarbonis L108...
Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

J. Biomol. Screen. 15 , 314-20, (2010)

Protein stabilization upon ligand binding has frequently been used to identify ligands for soluble proteins. Methods such as differential scanning fluorimetry (DSF) and differential static light scatt...
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

Proc. Natl. Acad. Sci. U. S. A. 103 , 15835-40, (2006)

The 3D structures of human therapeutic targets are enabling for drug discovery. However, their purification and crystallization remain rate determining. In individual cases, ligands have been used to ...

 Synonyms

5'-Deoxyadenosylcobalamin
a-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
DBC
5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
Coenzyme B12
Dibenzcozamide
Coenzyme B12
DBC coenzyme
Adenosyl cobalamine
Indusil T
α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
Vitamin B12 coenzyme
5,6-Dimethylbenzimidazolylcobamide 5'-Deoxyadenosine
Dimebenzcozamide
Adenosyl-B12
Calomide
AdoCbl
DBC (VAN)
Cobamamide
Cobalamine coenzyme
Deoxyadenosylcobalamin
5'-Deoxyadenosylcobalamine
Cobalamin coenzyme
a-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
Co-(5'-Deoxy-5'-adenosyl)-a-(5,6-dimethyl-1H-benzimidazolyl)cobamide
5'-Deoxyadenosyl Vtamin B12
Funacomide
Dibencozide
Desoxyadenosylcobalamine
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  • Product Name: Cobamamide
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  • Purity: 98.0%
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Chemsrc provides coenzyme B12(CAS#:13870-90-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coenzyme B12 are included as well.>> amp version: coenzyme B12

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