GSK J5 HCl
Modify Date: 2024-01-13 18:01:38
GSK J5 HCl structure
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Common Name | GSK J5 HCl | ||
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| CAS Number | 1797983-32-4 | Molecular Weight | 453.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H28ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK J5 HClGSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group[1]. |
| Name | GSK-J5 hydrochloride |
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| Description | GSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group[1]. |
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| Related Catalog | |
| In Vitro | GSK-J5 (25 μM) has no effects at inhibiting the LPS-induced response of human primary macrophages derived from healthy volunteers. While GSK-J4 significantly reduced the expression of 16 of 34 LPS-driven cytokines as assessed by PCR array, such as TNF-α[1]. GSK-J5 (30 μM; 6 hours) is the inactive isomer of GSK-J4, has no effect on TNF-α protein production. But neither GSK-J4 nor GSK-J5 directly affects the levels of LPS-induced JMJD3 or of LPS-independent UTX and EZH2[1]. GSK-J5 (30 μM; 1 hour) can not prevent the LPS-induced loss of H3K27me3 associated with the TNFA TSS or block the recruitment of RNA polymerase II to this locus but GSK-J5 can. Finally, GSK-J4, but not GSK-J5, blocks the production of TNF-α by macrophages derived from patients with rheumatoid arthritis[1]. |
| References |
| Molecular Formula | C24H28ClN5O2 |
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| Molecular Weight | 453.96 |