GSK-J2
Modify Date: 2024-01-06 18:12:23
GSK-J2 structure
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Common Name | GSK-J2 | ||
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| CAS Number | 1394854-52-4 | Molecular Weight | 389.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK-J2GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A. |
| Name | sodium,3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate |
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| Synonym | More Synonyms |
| Description | GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A. |
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| Related Catalog | |
| In Vitro | GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC50 of > 100 μM and 49 μM, respectively[1]. |
| References |
[1]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2. |
| Molecular Formula | C22H23N5O2 |
|---|---|
| Molecular Weight | 389.45 |
| PSA | 94.07000 |
| LogP | 1.83370 |
| Storage condition | 2-8℃ |
| Sodium 3-{[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]amino}propanoate |
| β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, sodium salt (1:1) |
| gsk-j2 |