N-Boc-PEG5-alcohol

Modify Date: 2024-01-09 17:34:09

N-Boc-PEG5-alcohol Structure
N-Boc-PEG5-alcohol structure
Common Name N-Boc-PEG5-alcohol
CAS Number 1404111-67-6 Molecular Weight 337.409
Density 1.1±0.1 g/cm3 Boiling Point 451.5±40.0 °C at 760 mmHg
Molecular Formula C15H31NO7 Melting Point N/A
MSDS N/A Flash Point 226.8±27.3 °C

 Use of N-Boc-PEG5-alcohol


N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl (14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)carbamate
Synonym More Synonyms

 N-Boc-PEG5-alcohol Biological Activity

Description N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 451.5±40.0 °C at 760 mmHg
Molecular Formula C15H31NO7
Molecular Weight 337.409
Flash Point 226.8±27.3 °C
Exact Mass 337.210052
LogP -0.67
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.461
Storage condition -20°C

 Synonyms

2-Methyl-2-propanyl (14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)carbamate
Carbamic acid, N-(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)-, 1,1-dimethylethyl ester