Tos-PEG12-Tos

Modify Date: 2024-01-08 13:07:12

Tos-PEG12-Tos Structure
Tos-PEG12-Tos structure
Common Name Tos-PEG12-Tos
CAS Number 1456708-45-4 Molecular Weight 855.019
Density 1.2±0.1 g/cm3 Boiling Point 833.3±65.0 °C at 760 mmHg
Molecular Formula C38H62O17S2 Melting Point N/A
MSDS N/A Flash Point 457.8±34.3 °C

 Use of Tos-PEG12-Tos


Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tos-PEG13-Tos
Synonym More Synonyms

 Tos-PEG12-Tos Biological Activity

Description Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 833.3±65.0 °C at 760 mmHg
Molecular Formula C38H62O17S2
Molecular Weight 855.019
Flash Point 457.8±34.3 °C
Exact Mass 854.342834
LogP -0.88
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.507

 Synonyms

MFCD28334513
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate)
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diol, bis(4-methylbenzenesulfonate)