Tos-PEG2-Boc

Modify Date: 2024-01-10 11:56:27

Tos-PEG2-Boc Structure
Tos-PEG2-Boc structure
Common Name Tos-PEG2-Boc
CAS Number 1309666-78-1 Molecular Weight 344.423
Density 1.2±0.1 g/cm3 Boiling Point 460.6±30.0 °C at 760 mmHg
Molecular Formula C16H24O6S Melting Point N/A
MSDS N/A Flash Point 232.3±24.6 °C

 Use of Tos-PEG2-Boc


Tos-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tos-PEG2-t-butyl ester
Synonym More Synonyms

 Tos-PEG2-Boc Biological Activity

Description Tos-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 460.6±30.0 °C at 760 mmHg
Molecular Formula C16H24O6S
Molecular Weight 344.423
Flash Point 232.3±24.6 °C
Exact Mass 344.129364
LogP 2.81
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.501

 Safety Information

Hazard Codes Xi

 Synonyms

Propanoic acid, 3-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD22201525
2-Methyl-2-propanyl 3-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)propanoate
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