Tos-PEG2-CH2COOH

Modify Date: 2024-01-15 10:47:13

Tos-PEG2-CH2COOH Structure
Tos-PEG2-CH2COOH structure
Common Name Tos-PEG2-CH2COOH
CAS Number 1807537-35-4 Molecular Weight 318.343
Density 1.3±0.1 g/cm3 Boiling Point 512.8±40.0 °C at 760 mmHg
Molecular Formula C13H18O7S Melting Point N/A
MSDS N/A Flash Point 263.9±27.3 °C

 Use of Tos-PEG2-CH2COOH


Tos-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tos-PEG3-CH2CO2H
Synonym More Synonyms

 Tos-PEG2-CH2COOH Biological Activity

Description Tos-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 512.8±40.0 °C at 760 mmHg
Molecular Formula C13H18O7S
Molecular Weight 318.343
Flash Point 263.9±27.3 °C
Exact Mass 318.077332
LogP 0.37
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.526

 Synonyms

[2-(2-{[(4-Methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]acetic acid
MFCD27977495
Acetic acid, 2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-