Mal-PEG3-alcohol

Modify Date: 2024-03-02 14:20:29

Mal-PEG3-alcohol Structure
Mal-PEG3-alcohol structure
Common Name Mal-PEG3-alcohol
CAS Number 146551-23-7 Molecular Weight 229.230
Density 1.3±0.1 g/cm3 Boiling Point 393.8±27.0 °C at 760 mmHg
Molecular Formula C10H15NO5 Melting Point N/A
MSDS N/A Flash Point 192.0±23.7 °C

 Use of Mal-PEG3-alcohol


Mal-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-PEG3-alcohol
Synonym More Synonyms

 Mal-PEG3-alcohol Biological Activity

Description Mal-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 393.8±27.0 °C at 760 mmHg
Molecular Formula C10H15NO5
Molecular Weight 229.230
Flash Point 192.0±23.7 °C
Exact Mass 229.095016
LogP -1.25
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.521

 Synonyms

8-(N-maleimidyl)-3,6-dioxaoctan-1-ol
1H-Pyrrole-2,5-dione, 1-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-
1-{2-[2-(2-Hydroxyethoxy)ethoxy]ethyl}-1H-pyrrole-2,5-dione
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