Cortodoxone

Modify Date: 2026-07-01 05:09:49

Cortodoxone structure	Common Name	Cortodoxone
	CAS Number	152-58-9	Molecular Weight	346.461
	Density	1.2±0.1 g/cm3	Boiling Point	524.5±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₀O₄	Melting Point	205-208 °C
	MSDS	USA	Flash Point	285.1±26.6 °C
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	11-deoxycortisol
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	524.5±50.0 °C at 760 mmHg
Melting Point	205-208 °C
Molecular Formula	C₂₁H₃₀O₄
Molecular Weight	346.461
Flash Point	285.1±26.6 °C
Exact Mass	346.214417
PSA	74.60000
LogP	2.74
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.578
InChIKey	WHBHBVVOGNECLV-OBQKJFGGSA-N
SMILES	CC12CCC(=O)C=C1CCC1C2CCC2(C)C1CCC2(O)C(=O)CO
Storage condition	-20°C Freezer

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Cortodoxone MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5011500

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17,21-dihydroxy-

CAS REGISTRY NUMBER :: 152-58-9

BEILSTEIN REFERENCE NO. :: 2511358

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H30-O4

MOLECULAR WEIGHT :: 346.51

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F,T
Risk Phrases	R22;R24/25
Safety Phrases	S24/25-S22
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
RTECS	TU5011500

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:640-87-9 reichstein's su... CAS#:110801-53-1 (8R,10R,13S,Z)-... CAS#:20380-17-0 21-bromo-17α-hy... CAS#:1807-15-4 Pregn-4-ene-3,2...
CAS#:1096-38-4 16-Dehydroproge... CAS#:1097-51-4 (16α)-16,17-Epo... CAS#:387-79-1 17a-Hydroxypreg... CAS#:2827-40-9 21-bromo-3β,17α...
CAS#:84542-27-8 (8R,9S,10R,13S,... CAS#:67-56-1 Methanol
DownStream 10
CAS#:50-23-7 Hydrocortisone CAS#:53-06-5 Cortisone CAS#:63-05-8 Androstenedione CAS#:566-35-8 11-Epicortisol
CAS#:595-18-6 Pregn-4-ene-3,2... CAS#:2899-95-8 20-hydroxycortisol CAS#:1807-15-4 Pregn-4-ene-3,2... CAS#:57-83-0 Progesterone
CAS#:64-85-7 Desoxycorticosterone CAS#:302-97-6 4-Androsten-3-o...

This table lists relevant public references with title, journal and publication metadata for this compound.

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Permeability of the compound in PBS and EtOH by PAMPA method
Source: ChEMBL
Target: N/A
External Id: CHEMBL3412995

Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201

Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN

Total 464, Current Page 1 of 47

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

11-deoxy-17-hydroxy-Corticosterone

CORTEXOLONE

17-Hydroxy-11-desoxy-corticosterone

SK&F 3050

4-Pregnene-17α,21-diol-3,20-dione

17-(1-Keto-2-hydroxyethyl)-4-androsten-17a-ol-3-one

11-Deoxycortisol

11-deoxy-Cortisol

17α,21-Dihydroxy-4-pregnene-3,20-dione

11-dioxy-cortiso

Reichstein S

17,21-Dihydroxyprogesterone

17,21-Dihydroxypregn-4-ene-3,20-dione

Reichstein's substance S

11-Desoxycortisone

Cortodoxone

11-Desoxycortisol

Reichstein's "Substance S"

17-Hydroxy-11-deoxycorticosterone

4-Pregnene-17a,21-diol-3,20-dione

17,21-Dihydroxy-4-pregnene-3,20-dione

11-Deoxy-17-hydroxycorticosterone

17-hydroxydesoxycorticosterone

11-dioxycortisol

EINECS 205-805-2

17,21-Dihydroxy-pregn-4-ene-3,20-dione

skf3050

MFCD00003662

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of 11-deoxycortisol?

A: Molecular weight of 11-deoxycortisol is 346.461.

Q: What are the downstream products of 11-deoxycortisol?

A: Related downstream products(CAS) of 11-deoxycortisol: 50-23-7;53-06-5;63-05-8;566-35-8;595-18-6;2899-95-8;1807-15-4;57-83-0;64-85-7;302-97-6.

Q: What is the English name of 11-deoxycortisol?

A: The English name of 11-deoxycortisol is 11-deoxycortisol.

Q: What is the molecular formula of 11-deoxycortisol?

A: Molecular formula of 11-deoxycortisol is C21H30O4.

Q: What is the SMILES notation of 11-deoxycortisol?

A: SMILES notation of 11-deoxycortisol is CC12CCC(=O)C=C1CCC1C2CCC2(C)C1CCC2(O)C(=O)CO.

Q: What are the storage conditions for 11-deoxycortisol?

A: Storage conditions for 11-deoxycortisol: -20°C Freezer.

Q: What are the upstream materials of 11-deoxycortisol?

A: Related upstream materials(CAS) of 11-deoxycortisol: 640-87-9;110801-53-1;20380-17-0;1807-15-4;1096-38-4;1097-51-4;387-79-1;2827-40-9;84542-27-8;67-56-1.

Q: What is the boiling point of 11-deoxycortisol?

A: Boiling point of 11-deoxycortisol is 524.5±50.0 °C at 760 mmHg.

Q: What is the safety information for 11-deoxycortisol?

A: Safety information for 11-deoxycortisol: S24/25-S22.

Q: What is the CAS number of 11-deoxycortisol?

A: CAS number of 11-deoxycortisol is 152-58-9.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
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Cortodoxone

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Precursor & DownStream

Articles36

CortodoxoneBioassay

Synonyms

Cortodoxone | FAQ

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.