Hydrocortisone structure
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Common Name | Hydrocortisone | ||
|---|---|---|---|---|
| CAS Number | 50-23-7 | Molecular Weight | 362.460 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 566.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H30O5 | Melting Point | 211-214 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 310.4±26.6 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
Use of HydrocortisoneHydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | cortisol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3]. |
| Cell Assay | Cells are plated on top of collagen IV-coated transwell chambers for six-well plates (24 mm diameter, membrane material: polyethylene terephthalate (PET), 0.4 μm pores, pore density 1.6×106 cm2) at densities of 2.5×104 cells cm2 per well. When they have reached confluence at day 5, the different experimental sets of cells are transferred to differentiation medium containing reduced amounts of FCS and treated with TNFα or hydrocortisone as indicated. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 566.5±50.0 °C at 760 mmHg |
| Melting Point | 211-214 °C(lit.) |
| Molecular Formula | C21H30O5 |
| Molecular Weight | 362.460 |
| Flash Point | 310.4±26.6 °C |
| Exact Mass | 362.209320 |
| PSA | 94.83000 |
| LogP | 1.43 |
| Vapour Pressure | 0.0±3.5 mmHg at 25°C |
| Index of Refraction | 1.595 |
| InChIKey | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| SMILES | CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R62;R63 |
| Safety Phrases | S36/37-S45 |
| RIDADR | 2811.0 |
| WGK Germany | 3 |
| RTECS | GM8925000 |
| Hazard Class | 6.1 |
| HS Code | 2937210000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 9 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2937210000 |
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This table lists relevant public references with title, journal and publication metadata for this compound.
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Functional consequence of the MET-T1010I polymorphism in breast cancer.
Oncotarget 6(5) , 2604-14, (2015) Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor rec... |
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Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
PLoS ONE 9(7) , e101824, (2014) Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon ... |
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MYC is a critical target of FBXW7.
Oncotarget 6(5) , 3292-305, (2015) MYC deregulation is a driver of many human cancers. Altering the balance of MYC protein levels at the level of transcription, protein stability, or turnover is sufficient to transform cells to a tumor... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Medicort |
| 11b,17,21-Trihydroxyprogesterone |
| 17a-Hydroxycorticosterone |
| H-Cort |
| (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione |
| 11β,17,21-Trihydroxyprogesterone |
| Cleiton |
| Hydrocortisone |
| MFCD00011654 |
| (11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione |
| Hydroxycorticosterone |
| Hydrocort |
| Kendall's compound F |
| (11b)-11,17,21-trihydroxypregn-4-ene-3,20-dione |
| 4-Pregnene-11b,17a,21-triol-3,20-dione |
| 17-hydroxycorticosterone |
| Hydrocorticosterone |
| 11,17,21-trihydroxy-pregn-4-ene-3,20-dione |
| Hytone |
| Alacort |
| Signef |
| (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one |
| Efcortelin |
| Hydroxycortisone |
| Hycort |
| hidrocortisona |
| Zenoxone |
| hydrocortisonum |
| CCN 90306A |
| HVB |
| Hydrocortal |
| wycort |
| Optef |
| Hydroskin |
| Eye-Cort |
| EINECS 200-020-1 |
| 17α-Hydroxycorticosterone |
| 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of cortisol? |
| A: Polar surface area (PSA) of cortisol is 94.83000. |
| Q: What are the uses of cortisol? |
| A: Main uses of cortisol: Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. |
| Q: What is the melting point of cortisol? |
| A: Melting point of cortisol is 211-214 °C(lit.). |
| Q: What is the molecular formula of cortisol? |
| A: Molecular formula of cortisol is C21H30O5. |
| Q: What is the molecular weight of cortisol? |
| A: Molecular weight of cortisol is 362.460. |
| Q: What is the InChIKey of cortisol? |
| A: InChIKey of cortisol is JYGXADMDTFJGBT-VWUMJDOOSA-N. |
| Q: What is the CAS number of cortisol? |
| A: CAS number of cortisol is 50-23-7. |
| Q: What are the upstream materials of cortisol? |
| A: Related upstream materials(CAS) of cortisol: 50-03-3;53-06-5;101524-47-4;76338-54-0;104117-71-7;50-04-4;102213-14-9;64313-94-6;566-35-8;102030-55-7. |
| Q: What is the safety information for cortisol? |
| A: Safety information for cortisol: S36/37-S45. |
| Q: What is the LogP of cortisol? |
| A: LogP of cortisol is 1.43. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |