RS-25344 hydrochloride
Modify Date: 2025-08-25 18:45:06
RS-25344 hydrochloride structure
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Common Name | RS-25344 hydrochloride | ||
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| CAS Number | 152815-28-6 | Molecular Weight | 411.799 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14ClN5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RS-25344 hydrochlorideRS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects[1][2]. |
| Name | RS 25344 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects[1][2]. |
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| Related Catalog | |
| Target |
PDE Ⅳ:0.28 nM (IC50) PDE Ⅰ:>100 μM (IC50) PDE Ⅱ:160 μM (IC50) PDE Ⅲ:330 μM (IC50) |
| In Vitro | RS-25344 hydrochloride (0-10 μM) is a potent inhibitor of sperm PDE activity, with an effective concentration of 0.3 nM and reaching maximum inhibition in the range of 100 nM[2]. |
| In Vivo | RS-25344 hydrochloride (5 mg/kg; i.p.; twice daily for 72 h) results in significant increases in stomach weights in wild type C57BL/6 mice[3]. RS-25344 hydrochloride (1 mg/kg; i.p.; 30 min prior to food bolus) increases gastric retention in mice[3]. |
| References |
| Molecular Formula | C19H14ClN5O4 |
|---|---|
| Molecular Weight | 411.799 |
| Exact Mass | 411.073425 |
| Hazard Codes | Xi |
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| 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (1:1) |
| Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-(3-nitrophenyl)-3-(4-pyridinylmethyl)-, hydrochloride (1:1) |
| 1-(3-Nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (1:1) |