Boc-N-Amido-PEG2-C2-azide

Modify Date: 2024-01-10 18:15:34

Boc-N-Amido-PEG2-C2-azide Structure
Boc-N-Amido-PEG2-C2-azide structure
Common Name Boc-N-Amido-PEG2-C2-azide
CAS Number 950683-55-3 Molecular Weight 274.31700
Density N/A Boiling Point N/A
Molecular Formula C11H22N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-N-Amido-PEG2-C2-azide


Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Carbamic acid, N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
Synonym More Synonyms

 Boc-N-Amido-PEG2-C2-azide Biological Activity

Description Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C11H22N4O4
Molecular Weight 274.31700
Exact Mass 274.16400
PSA 106.54000
LogP 1.69826

 Synonyms

BOC-NH-PEG(2)-N3 1-(T-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAZIDE
tert-Butyl 2-(2-azidoethoxy)ethoxyethylcarbamate
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