Azido-PEG2-azide
Azido-PEG2-azide structure
|
Common Name | Azido-PEG2-azide | ||
|---|---|---|---|---|
| CAS Number | 59559-06-7 | Molecular Weight | 200.19800 | |
| Density | 1.15 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C6H12N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Azido-PEG2-azideAzido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 1,8-Diazido-3,6-dioxaoctane |
|---|---|
| Synonym | More Synonyms |
| Description | Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.15 g/cm3 |
|---|---|
| Molecular Formula | C6H12N6O2 |
| Molecular Weight | 200.19800 |
| Exact Mass | 200.10200 |
| PSA | 117.96000 |
| LogP | 0.89332 |
|
~10%
Azido-PEG2-azide CAS#:59559-06-7 |
| Literature: Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424 |
|
~96%
Azido-PEG2-azide CAS#:59559-06-7 |
| Literature: Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488 |
|
~90%
Azido-PEG2-azide CAS#:59559-06-7 |
| Literature: Xiao, Junpeng; Tolbert, Thomas J. Organic Letters, 2009 , vol. 11, # 18 p. 4144 - 4147 |
|
~83%
Azido-PEG2-azide CAS#:59559-06-7 |
| Literature: Li, Yi; Dong, Jianming; Xun, Zhiqing; Zeng, Yi; Yu, Tianjun; Han, Yongbin; Chen, Jinping; Li, Ying-Ying; Yang, Guoqiang Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7931 - 7936 |
|
~%
Azido-PEG2-azide CAS#:59559-06-7 |
| Literature: Bouzide, Abderrahim; LeBerre, Nicolas; Sauve, Gilles Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8781 - 8783 |
| Precursor 4 | |
|---|---|
| DownStream 6 | |
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