6-Thioguanine structure
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Common Name | 6-Thioguanine | ||
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CAS Number | 154-42-7 | Molecular Weight | 167.192 | |
Density | 2.1±0.1 g/cm3 | Boiling Point | 460.7±37.0 °C at 760 mmHg | |
Molecular Formula | C5H5N5S | Melting Point | ≥300 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 232.4±26.5 °C | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of 6-Thioguanine6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. |
Name | tioguanine |
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Synonym | More Synonyms |
Description | 6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. |
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Related Catalog | |
Target |
IC50: 25 μM (PLpros), 40 μM (Recombinant human USP2)[3] |
In Vitro | 6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively[1]. 6-Thioguanine affects the methylation of cytosine residues by purified DNA methyltransferases including human DNMT1 and bacterial HpaII methylase. 6-Thioguanine (1 or 3 μM) decreases global cytosine methylation in Jurkat T cells and cytosine methylation in human cells at 3 μM[2]. 6-Thioguanine (18.75, 37.50, or 75.00 μM) adversely affects cell viability, but with no effect on LDH or ALT activity[3]. |
Cell Assay | Treatments consists of 3 thiopurines (azathioprine, 6-mercaptopurine, and 6-thioguanine) at each of 6 concentrations (0.468, 0.937, 1.875, 3.750, 7.500, and 15.000 μM). Each thiopurinee is dissolved in DMSO solution to achieve a concentration of 10 mg/mL. Sterile filtered maintenance medium is used to further dilute each thiopurine solution to each of the 6 treatment concentrations. Twenty-four hours after the hepatocytes are plated on 96-well culture[3]. |
References |
Density | 2.1±0.1 g/cm3 |
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Boiling Point | 460.7±37.0 °C at 760 mmHg |
Melting Point | ≥300 °C(lit.) |
Molecular Formula | C5H5N5S |
Molecular Weight | 167.192 |
Flash Point | 232.4±26.5 °C |
Exact Mass | 167.026566 |
PSA | 119.28000 |
LogP | -0.99 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 2.071 |
Water Solubility | soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T:Toxic; |
Risk Phrases | R25 |
Safety Phrases | S28-S36/37/39-S45-S28A |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | UP0740000 |
Packaging Group | III |
Hazard Class | 6.1 |
HS Code | 2933990090 |
~78% 6-Thioguanine CAS#:154-42-7 |
Literature: Tomsons, U. A.; Avots, A. A.; Kolesnikova, I. A. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 2 p. 136 - 138 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 2 p. 206 - 209 |
~% 6-Thioguanine CAS#:154-42-7 |
Literature: Pharmaceutical Chemistry Journal, , vol. 19, # 2 p. 136 - 138 Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 2 p. 206 - 209 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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MFCD00233553 |
2-Amino-6-methoxy purine |
tabloid |
2-aminomercaptopurine |
2-amino-9H-purine-6(1H)-thione |
tioguanin |
2-Amino-6-purinethiol |
bw5071 |
Tioguanine |
2-Amino-6-mercaptopurine,2-Amino-6-purinethiol |
7H-Purine-6-thiol, 2-amino- |
2-Amino-6-mercaptopurine |
2-Amino-1H-purine-6(7H)-thione |
6-Thioguanine |
lanvis |
Tg |
6-tg |
thioguanine |
thio-guanin |
6-thioguanidine |
EINECS 205-827-2 |
wellcomeu3b |
2-Amino-1,7-dihydro-6H-purine-6-thione |
6-Mercaptoguanine |