7-Hydroxycoumarinyl arachidonate
Modify Date: 2024-01-05 09:22:14
7-Hydroxycoumarinyl arachidonate structure
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Common Name | 7-Hydroxycoumarinyl arachidonate | ||
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| CAS Number | 161180-11-6 | Molecular Weight | 448.594 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 584.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C29H36O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 289.4±28.5 °C | |
Use of 7-Hydroxycoumarinyl arachidonate7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3]. |
| Name | (2-oxochromen-7-yl) icosa-5,8,11,14-tetraenoate |
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| Synonym | More Synonyms |
| Description | 7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3]. |
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| Related Catalog | |
| In Vitro | MAGL catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonate (7-HCA) into arachidonic acid (AA) and 7-HC. Release of 7-HC, which is fluorescent, is monitored over time with excitation (Ex) at 355 nm and emission (Em) at 460 nm[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 584.7±50.0 °C at 760 mmHg |
| Molecular Formula | C29H36O4 |
| Molecular Weight | 448.594 |
| Flash Point | 289.4±28.5 °C |
| Exact Mass | 448.261353 |
| PSA | 56.51000 |
| LogP | 8.02 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.545 |
| Hazard Codes | F: Flammable;Xi: Irritant; |
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| Risk Phrases | R11 |
| Safety Phrases | 7-16-26-36 |
| RIDADR | UN 1170 3/PG 2 |
| 7-HC-arachidonate |
| Umbelliferyl Arachidonate |
| 2-Oxo-2H-chromen-7-yl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate |
| 5,8,11,14-Eicosatetraenoic acid, 2-oxo-2H-1-benzopyran-7-yl ester, (5Z,8Z,11Z,14Z)- |