UNC-2170
Modify Date: 2024-01-01 20:01:33
UNC-2170 structure
|
Common Name | UNC-2170 | ||
|---|---|---|---|---|
| CAS Number | 1648707-58-7 | Molecular Weight | 313.233 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 419.6±30.0 °C at 760 mmHg | |
| Molecular Formula | C14H21BrN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 207.6±24.6 °C | |
Use of UNC-2170UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1]. |
| Name | 3-Bromo-N-[3-(Tert-Butylamino)propyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | UNC-2170 (500 µM) results in a significant increase in soluble 53BP1 as compared to untreated lysates or lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 µM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 419.6±30.0 °C at 760 mmHg |
| Molecular Formula | C14H21BrN2O |
| Molecular Weight | 313.233 |
| Flash Point | 207.6±24.6 °C |
| Exact Mass | 312.083710 |
| LogP | 2.99 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.534 |
| 3-Bromo-N-[3-(Tert-Butylamino)propyl]benzamide |
| 3-Bromo-N-{3-[(2-methyl-2-propanyl)amino]propyl}benzamide |
| Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]- |