| Description |
Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF2α and mCRF2β, respectively.
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| Related Catalog |
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| Target |
Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)[1]
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| In Vitro |
Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively[1].
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| In Vivo |
Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].
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| References |
[1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. [2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.
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