Urocortin human
Modify Date: 2024-01-02 19:00:58
Urocortin human structure
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Common Name | Urocortin human | ||
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| CAS Number | 176591-49-4 | Molecular Weight | 4696.24 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C204H337N63O64 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Urocortin humanUrocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively. |
| Name | Urocortin, human |
|---|---|
| Synonym | More Synonyms |
| Description | Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively. |
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| Related Catalog | |
| Target |
Ki: 0.4 nM (hCRF1, cell assay), 0.3 nM (rCRF2α, cell assay), and 0.5 nM (mCRF2β, cell assay)[1] |
| In Vitro | Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively[1]. |
| In Vivo | Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2]. |
| References |
[2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92. |
| Molecular Formula | C204H337N63O64 |
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| Molecular Weight | 4696.24 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
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Therapeutic effects of human urocortin-1, -2 and -3 in intracerebral hemorrhage of rats.
Neuropeptides 52 , 89-96, (2015) Urocortin exerts neuroprotective effects in intracerebral hemorrhage (ICH) of rats. For pre-clinical trial, we intended to study the neuroprotective efficacy of human UCN (hUCN)-1, -2 and -3 in treati... |
| MFCD00802621 |
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- Product Name: Urocortinhuman
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- Purity: 98.0%
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