Azide-PEG3-Tos

Modify Date: 2024-01-10 10:32:04

Azide-PEG3-Tos Structure
Azide-PEG3-Tos structure
Common Name Azide-PEG3-Tos
CAS Number 178685-33-1 Molecular Weight 329.37200
Density N/A Boiling Point N/A
Molecular Formula C13H19N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azide-PEG3-Tos


Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

 Names

Name 8-azido-3,6-dioxaoctyl tosylate
Synonym More Synonyms

 Azide-PEG3-Tos Biological Activity

Description Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

PEGs

Non-cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431.

[2]. Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.

 Chemical & Physical Properties

Molecular Formula C13H19N3O5S
Molecular Weight 329.37200
Exact Mass 329.10500
PSA 119.96000
LogP 2.57736

 Synonyms

2-(2-(2-azidoethoxy)ethoxy)ethyl toluenesulfonate
toluene 4-sulfonic acid 2-[2-(2-azidoethoxy)ethoxy] ethyl ester
2-[2-(2-azidoethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
2-(2-(2-azidoethoxy)ethoxy)ethyl tosylate
α-azidodeoxy-ω-O-tosyltriethyleneglycol
2-(2-(2-azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester
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