SUVN-502 mesylate

Modify Date: 2025-08-25 14:06:11

SUVN-502 mesylate Structure
SUVN-502 mesylate structure
Common Name SUVN-502 mesylate
CAS Number 1791396-46-7 Molecular Weight 670.61
Density N/A Boiling Point N/A
Molecular Formula C23H32BrN3O9S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SUVN-502 mesylate


Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].

 Names

Name Masupirdine mesylate

 SUVN-502 mesylate Biological Activity

Description Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].
Related Catalog
Target

5-HT6 Receptor:2.04 nM (Ki)

References

[1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.

 Chemical & Physical Properties

Molecular Formula C23H32BrN3O9S3
Molecular Weight 670.61
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