Propargyl-PEG2-Boc

Modify Date: 2024-01-19 17:42:48

Propargyl-PEG2-Boc Structure
Propargyl-PEG2-Boc structure
Common Name Propargyl-PEG2-Boc
CAS Number 1807503-80-5 Molecular Weight 228.285
Density 1.0±0.1 g/cm3 Boiling Point 290.5±20.0 °C at 760 mmHg
Molecular Formula C12H20O4 Melting Point N/A
MSDS N/A Flash Point 121.7±21.8 °C

 Use of Propargyl-PEG2-Boc


Propargyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propargyl-PEG2-t-butyl ester
Synonym More Synonyms

 Propargyl-PEG2-Boc Biological Activity

Description Propargyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 290.5±20.0 °C at 760 mmHg
Molecular Formula C12H20O4
Molecular Weight 228.285
Flash Point 121.7±21.8 °C
Exact Mass 228.136154
LogP 1.61
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.448

 Synonyms

PROPARGYL-PEG2-CH2CH2COOTBU
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