Tos-PEG2-O-Propargyl

Modify Date: 2024-01-07 22:34:22

Tos-PEG2-O-Propargyl structure	Common Name	Tos-PEG2-O-Propargyl
	CAS Number	1119249-30-7	Molecular Weight	298.35500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₈O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tos-PEG2-O-Propargyl

Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].

Name	2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate
Synonym	More Synonyms

Description	Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Hazard Codes	Xi

2-(2-(prop-2-ynyloxy)ethoxy)ethyl 4-methylbenzenesulfonate

3,6-dioxanon-8-yn-1-yl p-toluenesulfonate

1-O-tosyl-3,6-dioxanon-8-yne

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Price: ￥800/5 mg

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