Bis-PEG4-sulfonic acid

Modify Date: 2024-01-08 16:49:36

Bis-PEG4-sulfonic acid Structure
Bis-PEG4-sulfonic acid structure
Common Name Bis-PEG4-sulfonic acid
CAS Number 1807539-08-7 Molecular Weight 366.406
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C10H22O10S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bis-PEG4-sulfonic acid


Bis-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bis-PEG4-sulfonic acid
Synonym More Synonyms

 Bis-PEG4-sulfonic acid Biological Activity

Description Bis-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C10H22O10S2
Molecular Weight 366.406
Exact Mass 366.065430
LogP -4.76
Index of Refraction 1.505

 Synonyms

3,6,9,12-Tetraoxatetradecane-1,14-disulfonic acid
MFCD28976669