Acid-C2-PEG3-NHS ester

Modify Date: 2024-01-10 09:53:23

Acid-C2-PEG3-NHS ester Structure
Acid-C2-PEG3-NHS ester structure
Common Name Acid-C2-PEG3-NHS ester
CAS Number 1835759-79-9 Molecular Weight 347.318
Density 1.4±0.1 g/cm3 Boiling Point 516.1±60.0 °C at 760 mmHg
Molecular Formula C14H21NO9 Melting Point N/A
MSDS N/A Flash Point 265.9±32.9 °C

 Use of Acid-C2-PEG3-NHS ester


Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Acid-PEG3-NHS ester
Synonym More Synonyms

 Acid-C2-PEG3-NHS ester Biological Activity

Description Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 516.1±60.0 °C at 760 mmHg
Molecular Formula C14H21NO9
Molecular Weight 347.318
Flash Point 265.9±32.9 °C
Exact Mass 347.121643
LogP -2.71
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.516

 Synonyms

ACID-PEG3-NHS ESTER
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