GNE 0723

Modify Date: 2024-01-09 19:57:44

GNE 0723 structure	Common Name	GNE 0723
	CAS Number	1883518-31-7	Molecular Weight	467.776
	Density	1.8±0.1 g/cm3	Boiling Point	505.2±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₈ClF₆N₅OS	Melting Point	N/A
	MSDS	N/A	Flash Point	259.4±32.9 °C

Use of GNE 0723

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

Name	GNE 0723
Synonym	More Synonyms

Description	GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	EC50: 21 nM (GluN2A), 7.4 μM (GluN2C), 6.2 μM (GluN2D)[1]
In Vitro	GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].
References	[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

Density	1.8±0.1 g/cm3
Boiling Point	505.2±60.0 °C at 760 mmHg
Molecular Formula	C₁₆H₈ClF₆N₅OS
Molecular Weight	467.776
Flash Point	259.4±32.9 °C
Exact Mass	467.004242
LogP	2.89
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.680

Cyclopropanecarbonitrile, 2-[7-[[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-5-oxo-2-(trifluoromethyl)-5H-thiazolo[3,2-a]pyrimidin-3-yl]-, (1R,2R)-

(1R,2R)-2-[7-{[5-Chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-5-oxo-2-(trifluoromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropanecarbonitrile

MFCD30829912

GNE 0723

Use of GNE 0723

Names

GNE 0723 Biological Activity

Chemical & Physical Properties

Synonyms