PROTAC Linker 16

Modify Date: 2024-01-01 23:46:36

PROTAC Linker 16 Structure
PROTAC Linker 16 structure
Common Name PROTAC Linker 16
CAS Number 37860-51-8 Molecular Weight 502.59800
Density 1.242 g/mL at 25ºC(lit.) Boiling Point 635ºC at 760 mmHg
Molecular Formula C22H30O9S2 Melting Point N/A
MSDS Chinese USA Flash Point >230 °F
Symbol GHS07
GHS07
Signal Word Warning

 Use of PROTAC Linker 16


PROTAC Linker 16 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name Tetraethylene Glycol DI-P-Tosylate
Synonym More Synonyms

 PROTAC Linker 16 Biological Activity

Description PROTAC Linker 16 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.242 g/mL at 25ºC(lit.)
Boiling Point 635ºC at 760 mmHg
Molecular Formula C22H30O9S2
Molecular Weight 502.59800
Flash Point >230 °F
Exact Mass 502.13300
PSA 131.19000
LogP 4.62560
Index of Refraction n20/D 1.53(lit.)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2909309090

 Customs

HS Code 2909309090
Summary 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles1

More Articles
Bis(isoquinoline N-oxide) pincers as a new type of metal cation dual channel fluorosensor.

Org. Lett. 4(5) , 855-8, (2002)

[structure: see text] A new type of donor-spacer-acceptor podand system has been synthesized and proved as an efficient dual channel fluorosensor for Li+, Mg2+, and Ca2+. The known ability for the N-o...

 Synonyms

TETRAETHYLENE GLYCOL DI-P-TOSYLATE
Tetraethylene Glycol Bis(p-toluenesulfonate)
Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
Bis[2-(2-tosyloxyethoxy)ethyl] Ether
MFCD00075239
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