Diethylene glycol bis(p-toluenesulfonate)

Modify Date: 2024-01-05 03:43:41

Diethylene glycol bis(p-toluenesulfonate) Structure
Diethylene glycol bis(p-toluenesulfonate) structure
Common Name Diethylene glycol bis(p-toluenesulfonate)
CAS Number 7460-82-4 Molecular Weight 414.493
Density 1.3±0.1 g/cm3 Boiling Point 581.2±45.0 °C at 760 mmHg
Molecular Formula C18H22O7S2 Melting Point 87-89 °C(lit.)
MSDS Chinese USA Flash Point 305.3±28.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Diethylene glycol bis(p-toluenesulfonate)


Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Oxybis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
Synonym More Synonyms

  Biological Activity

Description Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 581.2±45.0 °C at 760 mmHg
Melting Point 87-89 °C(lit.)
Molecular Formula C18H22O7S2
Molecular Weight 414.493
Flash Point 305.3±28.7 °C
Exact Mass 414.080688
PSA 112.73000
LogP 2.70
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.554

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2904100000

 Customs

HS Code 2904100000
Summary 2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles1

More Articles
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Phosphorus. Sulfur. Silicon Relat. Elem. 179(3) , 535-41, (2004)

 Synonyms

Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate)
Oxydi-2,1-ethanediyl bis(4-methylbenzenesulfonate)
oxydiethane-2,1-diyl bis(4-methylbenzenesulfonate)
MFCD00026001
2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate
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