m-3M3FBS
m-3M3FBS structure
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Common Name | m-3M3FBS | ||
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| CAS Number | 200933-14-8 | Molecular Weight | 343.36400 | |
| Density | 1.316g/cm3 | Boiling Point | 420ºC at 760mmHg | |
| Molecular Formula | C16H16F3NO2S | Melting Point | 114-114.8ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 207.8ºC | |
Use of m-3M3FBSm-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3]. |
| Name | 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide |
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| Synonym | More Synonyms |
| Description | m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3]. |
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| Related Catalog | |
| In Vitro | m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells[1]. m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes[3]. m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis[3]. Cell Viability Assay[3] Cell Line: U937 and THP-1 cells Concentration: 50 μM Incubation Time: 24 hours Result: Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. Cell Viability Assay[3] Cell Line: U937 cells Concentration: 50 μM Incubation Time: 24 hours Result: The apoptotic rate of m-3M3FBS-treated cells was 53.9%. |
| References |
| Density | 1.316g/cm3 |
|---|---|
| Boiling Point | 420ºC at 760mmHg |
| Melting Point | 114-114.8ºC(lit.) |
| Molecular Formula | C16H16F3NO2S |
| Molecular Weight | 343.36400 |
| Flash Point | 207.8ºC |
| Exact Mass | 343.08500 |
| PSA | 54.55000 |
| LogP | 5.58520 |
| Vapour Pressure | 2.92E-07mmHg at 25°C |
| Index of Refraction | 1.547 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2935009090 |
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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| Tocris-1941 |
| Phospholipase C Activator,m-3M3FBS |
| N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide |
| m-3M3FBS |