Thalidomide-O-amido-C3-NH2

Modify Date: 2025-09-12 19:14:16

Thalidomide-O-amido-C3-NH2 Structure
Thalidomide-O-amido-C3-NH2 structure
Common Name Thalidomide-O-amido-C3-NH2
CAS Number 2022182-58-5 Molecular Weight 502.40
Density N/A Boiling Point N/A
Molecular Formula C20H21F3N4O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-O-amido-C3-NH2


E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) incorporates a CRBN ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) is a PROTAC precursor[1].

 Names

Name E3 Ligase Ligand-Linker Conjugates 52 (TFA)

 Thalidomide-O-amido-C3-NH2 Biological Activity

Description E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) incorporates a CRBN ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) is a PROTAC precursor[1].
Related Catalog
Target

Cereblon

References

[1]. Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262.

 Chemical & Physical Properties

Molecular Formula C20H21F3N4O8
Molecular Weight 502.40
InChIKey OKTNKIORKNBBAG-UHFFFAOYSA-N
SMILES NCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)F
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Price: ¥663/10 mM * 1 mL in DMSO

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