Thalidomide-O-amido-C5-NH2
Modify Date: 2025-08-27 09:34:26
Thalidomide-O-amido-C5-NH2 structure
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Common Name | Thalidomide-O-amido-C5-NH2 | ||
|---|---|---|---|---|
| CAS Number | 2360527-40-6 | Molecular Weight | 416.428 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 757.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H24N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 411.8±32.9 °C | |
Use of Thalidomide-O-amido-C5-NH2Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
| Name | N-(5-Aminopentyl)-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide |
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| Synonym | More Synonyms |
| Description | Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 757.3±60.0 °C at 760 mmHg |
| Molecular Formula | C20H24N4O6 |
| Molecular Weight | 416.428 |
| Flash Point | 411.8±32.9 °C |
| Exact Mass | 416.169586 |
| LogP | -0.48 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.599 |
| Hazard Codes | Xi |
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| Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- |
| N-(5-Aminopentyl)-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide |