Lin28-let-7a antagonist 1
Modify Date: 2024-01-09 10:13:37
Lin28-let-7a antagonist 1 structure
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Common Name | Lin28-let-7a antagonist 1 | ||
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| CAS Number | 2024548-03-4 | Molecular Weight | 583.59 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H29N5O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lin28-let-7a antagonist 1Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction. |
| Name | Lin28-let-7a antagonist 1 |
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| Description | Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction. |
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| Related Catalog | |
| Target |
IC50：4.03 μM (Lin28A-let-7a-1)[1]. |
| In Vitro | Lin28-let-7a antagonist 1 (compound 1) shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM. Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency. Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA. When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28[1]. |
| References |
| Molecular Formula | C31H29N5O7 |
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| Molecular Weight | 583.59 |
| Storage condition | 2-8°C |