Mal-amido-PEG6-acid

Modify Date: 2024-01-09 08:07:07

Mal-amido-PEG6-acid Structure
Mal-amido-PEG6-acid structure
Common Name Mal-amido-PEG6-acid
CAS Number 1334177-79-5 Molecular Weight 504.528
Density 1.2±0.1 g/cm3 Boiling Point 702.5±60.0 °C at 760 mmHg
Molecular Formula C22H36N2O11 Melting Point N/A
MSDS N/A Flash Point 378.7±32.9 °C

 Use of Mal-amido-PEG6-acid


Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 25-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-23-oxo-4,7,10,13,16,19-hexaoxa-22-azapentacosan-1-oic acid
Synonym More Synonyms

 Mal-amido-PEG6-acid Biological Activity

Description Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 702.5±60.0 °C at 760 mmHg
Molecular Formula C22H36N2O11
Molecular Weight 504.528
Flash Point 378.7±32.9 °C
Exact Mass 504.231903
LogP -2.97
Vapour Pressure 0.0±4.8 mmHg at 25°C
Index of Refraction 1.507
Storage condition 2-8°C

 Synonyms

4,7,10,13,16,19-Hexaoxa-22-azapentacosan-1-oic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-23-oxo-
25-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-23-oxo-4,7,10,13,16,19-hexaoxa-22-azapentacosan-1-oic acid
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