IACS-8803

Modify Date: 2025-09-01 20:29:46

IACS-8803 structure	Common Name	IACS-8803
	CAS Number	2095690-70-1	Molecular Weight	692.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₃FN₁₀O₉P₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IACS-8803

IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy[1].

Name	IACS-8803

Description	IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
Target	STING[1]
In Vivo	IACS-8803 shows a superior systemic anti-tumor response in the B16 murine model of melanoma[1].
References	[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.

Molecular Formula	C₂₀H₂₃FN₁₀O₉P₂S₂
Molecular Weight	692.53
InChIKey	CMVAAKLGZJHFOY-ILOIOECTSA-N
SMILES	Nc1ncnc2c1ncn2C1OC2COP(=O)(S)OC3C(O)C(COP(O)(=S)OC2C1F)OC3n1cnc2c(N)ncnc21

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