Bcl-2/Bcl-xl inhibitor 1

Modify Date: 2024-01-06 22:22:32

Bcl-2/Bcl-xl inhibitor 1 Structure
Bcl-2/Bcl-xl inhibitor 1 structure
Common Name Bcl-2/Bcl-xl inhibitor 1
CAS Number 2180923-05-9 Molecular Weight 882.42
Density N/A Boiling Point N/A
Molecular Formula C45H48ClN7O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bcl-2/Bcl-xl inhibitor 1


Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

 Names

Name Bcl-2/Bcl-xl inhibitor 1

 Bcl-2/Bcl-xl inhibitor 1 Biological Activity

Description Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].
Related Catalog
Target

Bcl-2:2 nM (IC50)

Bcl-xL:5.9 nM (IC50)

In Vitro Bcl-2/Bcl-xl inhibitor 1 (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells[1].
References

[1]. WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

 Chemical & Physical Properties

Molecular Formula C45H48ClN7O8S
Molecular Weight 882.42
Storage condition 2-8°C