Apoptosis inducer 9
Modify Date: 2024-01-08 18:42:48
Apoptosis inducer 9 structure
|
Common Name | Apoptosis inducer 9 | ||
|---|---|---|---|---|
| CAS Number | 2551067-10-6 | Molecular Weight | 601.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H55N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Apoptosis inducer 9Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents[1]. |
| Name | Apoptosis inducer 9 |
|---|
| Description | Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Apoptosis inducer 9 (Compound A1) (5-10 μM, 12 hours) induces apoptosis in HepG-2 cells in a concentration-dependent manner[1]. Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) triggers Cl-caspase-3, Cl-caspase-9 and Cl-PARP protein expression in HepG-2, thereby inducing apoptosis[1]. Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) induces apoptosis by triggering the mitochondrial apoptosis pathway[1]. Cell Viability Assay[1] Cell Line: HepG-2 cells Concentration: 5 and 10 μM Incubation Time: 12 hours Result: Apoptotic bodies appeared shrunken, nuclei shrunken and cells fragmented. The apoptosis rates at concentrations of 5 μM and 10 μM were 10.2% and 42.7%, respectively. Western Blot Analysis[1] Cell Line: HepG-2 cells Concentration: 0, 5, 10 and 20 μM Incubation Time: 24 hours Result: Triggered the caspase cascade in HepG-2 and the corresponding protein expression gradually increased. Western Blot Analysis[1] Cell Line: HepG-2 cells Concentration: 0, 5, 10 and 20 μM Incubation Time: 24 hours Result: Induced up-regulation of the expression of Bcl-2, Bax and p53 proteins, and increased the ratio of Bax/Bcl-2. |
| References |
| Molecular Formula | C34H55N3O4S |
|---|---|
| Molecular Weight | 601.88 |