Anticancer agent 65

Modify Date: 2024-01-12 12:16:06

Anticancer agent 65 structure	Common Name	Anticancer agent 65
	CAS Number	2407861-48-5	Molecular Weight	589.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₆₃NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Anticancer agent 65

Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].

Name	Anticancer agent 65

Description	Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP Bcl-2 Bax
In Vitro	Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2[1].
References	[1]. Ma L, Wang X, Li W, Miao D, Li Y, Lu J, Zhao Y. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives. Eur J Med Chem. 2020 Feb 1;187:111964.

Molecular Formula	C₃₆H₆₃NO₅
Molecular Weight	589.89

Anticancer agent 65

Use of Anticancer agent 65

Names

Anticancer agent 65 Biological Activity

Chemical & Physical Properties