Antitumor agent-69

Modify Date: 2024-01-03 08:58:01

Antitumor agent-69 structure	Common Name	Antitumor agent-69
	CAS Number	2417651-42-2	Molecular Weight	771.00
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₃H₆₂N₈O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antitumor agent-69

Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy[1].

Name	Antitumor agent-69

Description	Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
References	[1]. Yuan Y, et, al. Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem. 2022 Jun 9;65(11):7770-7785.

Molecular Formula	C₄₃H₆₂N₈O₅
Molecular Weight	771.00

Antitumor agent-69

Use of Antitumor agent-69

Names

Antitumor agent-69 Biological Activity

Chemical & Physical Properties