FGFR3-IN-3

Modify Date: 2024-01-14 22:50:44

FGFR3-IN-3 structure	Common Name	FGFR3-IN-3
	CAS Number	2428738-41-2	Molecular Weight	759.92
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₈H₄₉N₉O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FGFR3-IN-3

FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].

Name	FGFR3-IN-3

Description	FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR1:2.1 nM (IC50) FGFR2:3.1 nM (IC50) FGFR3:4.3 nM (IC50) FGFR4:74 nM (IC50)
References	[1]. Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.

Molecular Formula	C₃₈H₄₉N₉O₆S
Molecular Weight	759.92

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