KNa1.1 inhibitor 31
Modify Date: 2024-02-04 15:40:47
KNa1.1 inhibitor 31 structure
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Common Name | KNa1.1 inhibitor 31 | ||
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| CAS Number | 2540502-26-7 | Molecular Weight | 434.302 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H12F6N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KNa1.1 inhibitor 31KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF. |
| Name | KNa1.1 inhibitor 31 |
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| Description | KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF. |
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| References | 1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602. |
| Molecular Formula | C16H12F6N6O2 |
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| Molecular Weight | 434.302 |