Glucosylceramide synthase-IN-2
Modify Date: 2024-01-10 12:03:32
Glucosylceramide synthase-IN-2 structure
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Common Name | Glucosylceramide synthase-IN-2 | ||
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| CAS Number | 2597958-02-4 | Molecular Weight | 447.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20F3N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Glucosylceramide synthase-IN-2Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1]. |
| Name | Glucosylceramide synthase-IN-2 |
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| Description | Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1]. |
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| Related Catalog | |
| In Vitro | Glucosylceramide synthase-IN-2 (compound T-690) has no SERT inhibitory activity (IC50>10 μM). Glucosylceramide synthase-IN-2 does not affect GCase activity (EC50>300 μM)[1]. Glucosylceramide synthase-IN-2 (30 μM) does not potently inhibit hERG, CaV1.2, and NaV1.5 channels[1]. |
| In Vivo | Glucosylceramide synthase-IN-2 (compound T-690; po; 30, 100, 300 mg/kg) reduces GlcCer concentrations in the plasma and cerebral cortex in a dose-dependent manner in C57BL/6J mice[1]. Glucosylceramide synthase-IN-2 (po; 5 mg/kg) has a Cmax of 416 ng/mL. Glucosylceramide synthase-IN-2 shows good oral exposure (BA = 31%)[1]. Glucosylceramide synthase-IN-2 reveals good brain exposure (Cu,brain = 0.21 μM at 30 mg/kg dosing, 1 h)[1]. |
| References |
| Molecular Formula | C22H20F3N3O4 |
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| Molecular Weight | 447.41 |