Clathrin-IN-2

Modify Date: 2025-08-21 13:11:13

Clathrin-IN-2 structure	Common Name	Clathrin-IN-2
	CAS Number	2650733-69-8	Molecular Weight	426.15
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₈Br₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Clathrin-IN-2

Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1].

Name	Clathrin-IN-2

Description	Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Cytoskeleton >> Dynamin
In Vitro	Clathrin-IN-2 (Compound 8a) 可以抑制网格蛋白介导的内吞作用，IC50 值为 2.3 μM[1]。 Clathrin-IN-2 对 dyn I GTPase 具有抑制作用，IC50 值为 7.7 μM[1]。
References	[1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.

Molecular Formula	C₁₇H₁₈Br₂N₂O
Molecular Weight	426.15
InChIKey	XUBJEDZHBUPBKL-ZDUSSCGKSA-N
SMILES	CN(C)CC(O)Cn1c2ccc(Br)cc2c2cc(Br)ccc21

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