PI3K/AKT-IN-2
Modify Date: 2025-08-27 11:00:37
PI3K/AKT-IN-2 structure
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Common Name | PI3K/AKT-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 2684412-41-5 | Molecular Weight | 651.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H27BrO10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3K/AKT-IN-2PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin[1]. |
| Name | PI3K/AKT-IN-2 |
|---|
| Description | PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin[1]. |
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| Related Catalog | |
| Target |
MMP-2 |
| In Vitro | PI3K/AKT-IN-2 (Compound 12c) shows antiproliferative activity with IC50 values of 14.84 ± 1.53, 4.79 ± 0.71, 14.34 ± 0.57, 0.89 ± 0.023, >100 and 98.75 ± 1.59 µM against H460, MCF-7, A549, HGC-27, 293 T and GES-1 cells, respectively[1]. PI3K/AKT-IN-2 suppresses the expressions/activities of matrix metalloprotease (MMP)− 2, vimentin and up-regulation E-cadherin[1]. PI3K/AKT-IN-2 induces significant up-regulation of CDK1 proteins expression with a down-regulation of cyclin B1 and Cdc25C[1]. |
| References |
| Molecular Formula | C32H27BrO10 |
|---|---|
| Molecular Weight | 651.45 |