Bcl-2-IN-5
Modify Date: 2025-09-18 12:17:15
Bcl-2-IN-5 structure
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Common Name | Bcl-2-IN-5 | ||
|---|---|---|---|---|
| CAS Number | 2728752-20-1 | Molecular Weight | 1015.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C55H63FN8O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bcl-2-IN-5Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1]. |
| Name | Bcl-2-IN-5 |
|---|
| Description | Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1]. |
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| Related Catalog | |
| Target |
Bcl-2:0.12 nM (IC50) Bcl-2 D103Y:0.14 nM (IC50) Bcl-2 G101V:0.22 nM (IC50) |
| References |
| Molecular Formula | C55H63FN8O8S |
|---|---|
| Molecular Weight | 1015.20 |
| InChIKey | DDYYYKLOAZDKFR-ASPJDRGKSA-N |
| SMILES | COc1ccc(CN2CCN(C3CC4(C3)CN(c3ccc(C(=O)NS(=O)(=O)c5ccc(NCC6CCC(C)(O)CC6)c([N+](=O)[O-])c5)c(Oc5cnc6[nH]cc(F)c6c5)c3)C4)C(c3ccccc3C(C)C)C2)cc1 |