PF-6870961 hydrochloride
Modify Date: 2024-09-08 19:53:38
PF-6870961 hydrochloride structure
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Common Name | PF-6870961 hydrochloride | ||
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| CAS Number | 2857112-07-1 | Molecular Weight | 565.13 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H33ClN6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-6870961 hydrochloridePF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM[1]. |
| Name | PF-6870961 hydrochloride |
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| Description | PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM[1]. |
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| Related Catalog | |
| In Vivo | PF-6870961 hydrochloride (40 mg/kg；腹腔注射) 抑制饱食和禁食大鼠的食物摄入[1]。 Animal Model: Satiated and fasted rats model[1] Dosage: 2.5 mg/kg, 10 mg/kg, and 40 mg/kg Administration: Intraperitoneal injection Result: Significantly reduced food intake at 40 mg/kg. |
| References |
| Molecular Formula | C29H33ClN6O2S |
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| Molecular Weight | 565.13 |