PF-6870961
Modify Date: 2024-04-09 15:39:12
PF-6870961 structure
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Common Name | PF-6870961 | ||
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| CAS Number | 2857112-06-0 | Molecular Weight | 528.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H32N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-6870961PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM[1]. |
| Name | PF-6870961 |
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| Description | PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM[1]. |
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| Related Catalog | |
| In Vivo | PF-6870961 (40 mg/kg; i.p.) suppresses food intake in both satiated and fasted rats[1]. Animal Model: Satiated and fasted rats model[1] Dosage: 2.5 mg/kg, 10 mg/kg, and 40 mg/kg Administration: Intraperitoneal injection Result: Significantly reduced food intake at 40 mg/kg. |
| References |
| Molecular Formula | C29H32N6O2S |
|---|---|
| Molecular Weight | 528.67 |