Levalbuterol

Modify Date: 2024-01-02 19:26:43

Levalbuterol structure	Common Name	Levalbuterol
	CAS Number	34391-04-3	Molecular Weight	239.311
	Density	1.2±0.1 g/cm3	Boiling Point	433.5±40.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₂₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	159.5±17.9 °C

Use of Levalbuterol

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].

Name	(R)-salbutamol
Synonym	More Synonyms

Description	Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1]. Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1]. RT-PCR[1] Cell Line: Murine Club (MTCC) cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased 11β-HSD1 mRNA expression selectively.
In Vivo	Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3]. Animal Model: C57BL/6 female mice with a pulmonary allergic model[3] Dosage: 1 mg/kg Administration: Subcutaneous injection; 1 mg/kg; 14 days Result: Decreased pulmonary inflammation after OVA sensitization.
References	[1]. Randall MJ, et al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells.Front Endocrinol (Lausanne). 2015 Jan 12;5:236. [2]. Ferrada MA, et al. (R)-albuterol decreases immune responses: role of activated T cells.Respir Res. 2008 Jan 14;9:3.

Density	1.2±0.1 g/cm3
Boiling Point	433.5±40.0 °C at 760 mmHg
Molecular Formula	C₁₃H₂₁NO₃
Molecular Weight	239.311
Flash Point	159.5±17.9 °C
Exact Mass	239.152145
PSA	72.72000
LogP	0.01
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.566
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ6426700

CHEMICAL NAME :: 1,3-Benzenedimethanol, alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, (-)-

CAS REGISTRY NUMBER :: 34391-04-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H21-N-O3

MOLECULAR WEIGHT :: 239.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia Endocrine - changes in spleen weight

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,106,1996

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
HS Code	2922509090

(R)-α1-[[(1,1-d...

CAS#:348135-26-2

~93%

Levalbuterol

CAS#:34391-04-3

Literature: Merli, Valeriano; Mantovani, Silvia; Bianchi, Stefano; Daverio, Paola Patent: US2005/261368 A1, 2005 ; Location in patent: Page/Page column 7 ;

Methanol

CAS#:67-56-1

(R)-α1-[[(1,1-d...

CAS#:348135-26-2

~95%

Salbutamol EP i...

CAS#:870076-72-5

4-[2-(tert-buty...

CAS#:18910-70-8

Detail

Literature: Merli, Valeriano; Mantovani, Silvia; Bianchi, Stefano; Daverio, Paola Patent: US2005/261368 A1, 2005 ; Location in patent: Page/Page column 8-10 ;

(-)-(R)-2-(tert...

CAS#:238762-31-7

~10%

Levalbuterol

CAS#:34391-04-3

Literature: Fine Chemical Corporation Limited Patent: US6365756 B1, 2002 ; Location in patent: Example 13 ;

Precursor 3
CAS#:348135-26-2 (R)-α1-[[(1,1-d... CAS#:67-56-1 Methanol CAS#:238762-31-7 (-)-(R)-2-(tert...
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(-)-Albuterol

(R)-albuterol

R-Albuterol

Levosalbutamol

(a1R)-a1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol

(l)-albuterol

(R)-a1-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol

1,3-Benzenedimethanol, α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (αR)-

(-)-a1-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol

(R)-salbutamol

4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol

2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol

R-Salbutamol

UNII-EDN2NBH5SS

(-)-Salbutamol

Levalbuterol

Albuterol

MFCD00869868

1,3-Benzenedimethanol, α1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, (α1R)-

Salbutamol

DC Chemicals Limited
China
Product Name: Levosalbutamol
Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Salbutamol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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